Back in the 1950s and 1960s, when the US space program was going strong, the US government got a think tank together to investigate what would happen to humanity if we met another species.
One of the things that worried the think tank most was what would happen if it turned out that our knowledge was fundamentally flawed, and we lacked the capacity to the superior knowledge of another intelligent species. What would happen to our religions and our sciences?
Recent experiments in physics have suggested that our view of reality may be fundamentally flawed, in that there may be no objective reality either locally or non-locally. Whether this is true is debatable, but the implications for natural philosophy are profound.
In computation theory, it may turn out that our brains sit on an 'island of computation' from which a view of a more fundamental reality hits a brick wall and gets stuck. That is, the very fabric of our brain may make a fundamental understanding of reality computationally impossible. In this case, there would be a profound effect on the dominant academic paradigm of the last 500 years. We would have to shift to 'tending our garden'.
From a more religious point of view, the more I focus on the present moment, the more I realize how little I know. To me, what people can know is narrative. So what is your narrative? If you have one, then you truly know something unique and important.