All four of the forces in the universe create a distinct effect on all of the most basic subatomic forms of matter -- called elementary particles. When these particles interact with force carriers (called bosons), they become different particles. For example, when one of the most basic quantum particles -- the lepton -- encounters a weak-force boson, it becomes a neutrino. A lepton interacting with a photon (a boson that carries an electromagnetic charge) becomes an electron. So while there are limited numbers of the most basic particles, when they encounter the different forces, they change to become other, distinct particles. What's more, for every particle, there is an equally distinct anti-particle, for example an anti-quark or anti-neutrino. In total, these make up the elementary particles, and there are 28 of them.
Each of these distinct elementary particles has eight quantum numbers assigned to it, based on the charges each particle has. This brings the number of distinct particles to 224. These numbers helped Lisi make the particles fit into the E8 model. While the E8 is expressed as a 248-dimensional object in one way, it can also be expressed as an eight-dimensional object with 248 symmetries. Lisi used E8 within eight dimensions for his calculations. For the remaining 24 places unfilled by distinct known particles, Lisi used theoretical particles which are yet to be observed.
Take another look at E8, and notice how the lines radiate from each point:
Lisi assigned each of these 248 points to a particle, using the eight numbers based on their charges as coordinates within the eight dimensions. What he found was that, like the symmetries in the E8 group, quantum particles share the same relationship within the symmetrical object. He has hope that he has figured out a way to crack the theory of everything, because when he rotated the E8 filled with the force-influenced (including gravity) quantum particles, he found patterns emerging between particles and forces -- photons interacting with leptons, for example, created electrons. The connections shown within points on the E8 match up to real, known connections between particles in our physical world.
If Lisi's method is proven correct, then evaluating the E8 could show physicists how macro-scale gravity interacts with the other, highly-localized three forces.