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Neurotoxins

Discussion in 'Science and Technology' started by Entyqua, Nov 3, 2009.

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  1. Entyqua

    Entyqua Forgotten
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    I am writing a murder mystery for NaNoWriMo and need some help....I need a toxin that can either be breathed or ingested that will cause paralysis, while still leaving the victim conscious and able to feel. I know this is morbid...but this serial killer is very sick! Any ideas?

    Here is what I have considered
    Tetrodotoxin - While this is my first choice, i cant have the victim dying of respiratory failure first.

    Belladonna - but the side effects are so varied...I would worry the death would come of once again respiratory failure first.

    Curare, but everywhere I have read also says attacks the lungs first, and has to enter through blood stream





    Any other ideas? or know more about above materials that could be useful?
     
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  2. testing

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    OOOOOhhhh! I love a good murder mystery.

    Paralyzed but still able to feel?

    What about Botox? Doesn't botulism toxin cause lockjaw? That's sort of a kind of paralysis.
     
  3. Solar Empath

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    Was just reading about that. If ingested or inhaled it takes 12-18 hours to kick in. I assume that is far too slow for a serial killer
     
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  4. OP
    Entyqua

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    yes I need hours...

    Just read this about tetrodotoxin


    • The first symptoms occur 15 minutes to several hours postingestion of tetrodotoxin-containing food. A recent report on toxicity found that initial symptoms may occur up to 20 hours after ingestion.
    • Initial symptoms include lip and tongue paresthesias, followed by facial and extremity paresthesias and numbness.
    • Salivation, nausea, vomiting, and diarrhea with abdominal pain develop early.
    • Motor dysfunction with weakness, hypoventilation (may be from dysfunction of central and peripheral nervous systems), and speech difficulties then develop. A rapid ascending paralysis occurs over 4-24 hours. Extremity paralysis precedes bulbar paralysis, which is followed by respiratory muscle paralysis. Deep tendon reflexes are preserved early in the course of paralysis.
    • Finally, cardiac dysfunction with hypotension and dysrhythmias (bradycardia), central nervous system (CNS) dysfunction (eg, coma), and seizures develop. Patients with severe toxicity may have deep coma, fixed nonreactive pupils, apnea, and loss of all brain stem reflexes.
    • Death can occur within 4-6 hours. Typically, death occurs from respiratory muscle paralysis and respiratory failure.
     
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  5. testing

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    I think you need a good Pre-Synaptic Neurotoxin from a nice little snake, like this:
    http://www.toxinology.com/fusebox.cfm?staticaction=snakes/ns-venmed02.htm

    Oh, but I think you'd have to inject it. Bummer.
     
    #5 testing, Nov 3, 2009
    Last edited: Nov 3, 2009
  6. OP
    Entyqua

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    that is a bit of a bummer...I am sure I could figure out a way...but ugh thats just not how I picture this guy...he is only hands on after they cant move....
     
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  7. sassafras

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    I know that they created "zombies" with the neurotoxin from a pufferfish. I forgot where I heard that, though.
     
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  8. OP
    Entyqua

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    It was a myth...there was a book about it, and it was disproved in the eighties...Thats the tetrodotoxin I have in my list! lol
     
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  9. sassafras

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    Like I said, I heard it somewhere. I think it was Ripley's Believe it Or Not.

    Anyhow, what about looking for some pharmaceuticals that induce catatonia specifically? Adenosine is a possibility...
     
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  10. OP
    Entyqua

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    I like the idea of using pharmaceuticals too...Wiki on that one is confusing...I cant decide if its an upper or a downer! lol...I will research more of it!
     
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  11. sassafras

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    Some anti-psychotics induce catatonia. At a higher dose, perphenazine can induce paralysis. Tranquilizers are also handy-dandy for your serial killer. Or better yet, look up case studies of serial killers that fit that profile. Paul Bernardo is one of the most famous serial killers who drugged his victims.

    Still, if you're doing NanoWrimo, I would advise that you don't get too hung up on the little nitty-gritty details. You can always come back and revise if you didn't use the right drug/or your research doesn't add up. Just get the story done, girl!
     
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  12. OP
    Entyqua

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    Thats what I have done now...moved on...just getting it out...I want to be accurate, but i know i need to get moving!
     
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