I've been on Wellbutrin for about 5 years now with one 6 month break from it.
I started taking it after my Father passed and I had been under a lot of stress for a period of time leading up to his passing. I was very irritable, lacked focus, had lost interest in doing things that I enjoyed.
It has worked for me in that it has leveled out my mood so I am not so quick to anger or become overly pessimistic in my attitude.
Last year, I began to think maybe my taking it wasn't really necessary anymore. I met with my doctor to discuss it, and She agreed it wouldn't hurt as I could always go back, so I was given a plan to wean off of it.
The only other person that knew I took it other than my Wife was a coworker of mine.
I used her as control in my study.
After about 4 months passed, I felt I was falling back into my moodiness. My Wife wasn't really seeing it though.
A little more time passed when one day my coworker looked at me and said, "Are you not taking your happy pills? You sure have been a crabby bastard lately!"
That was all the proof I needed. I went back on it, and am back to being what I call normal.
That's my story.
Obviously, just because it has worked for me doesn't mean it will work for others. I feel I got lucky in that I didn't have to experiment with different medications before finding one that has worked.