Aside from the fact that I'm living proof of the mind rewiring itself...
I sincerely believe that the chemicals and electrical signals are tied to our spiritual selves, and that these systems interact with each other intimately - both sustaining and feeding on and off of one another. In order for the mind to reset, the spirit has to want to change. This is why the same stimuli can cause one person to adapt and another to remain unchanged. The trick in this equation is to leverage the spirit into making the choice.
Sorry if I got too Ni there...
Nah, I get it. I'm not quite sure I share you spiritual definition there and how those elements interact, but I can agree on the basic concept that the psyche/spirit/collective identity of the parts of the whole has to be highly motivated (consciously and unconsciously) to make some sort of change. Conscious motivation is easy. It can be as simple as saying: 'I want that, it looks good.'
Getting to the root of the unconscious wants and needs and that often self-contradicting mess of underlying meta-programs, however; is another story entirely. No wonder we look to systems to try and make sense of our head-space. It would be comforting to have one, over-arching explanation for everything and to work just within those parameters, just to keep things simple...
Obviously, though, that's not how it all works. That would be far too optimistic.
The brain is able to retain everything that it experiences. Recall, however, is the obvious barrier. We seem to trust our surface memories and the things that our filter-system has deemed important; but this gives us a very narrow view of the experiences and myriad of other filters we put in place that makes us who we are. I accept the position that the mind operates based on archetypes and automatically assembles information into pre-set packages and biases to support a pattern-based functioning. But there's only so many pattern filters that we can support consciously. Some filters get wait-listed into deeper, unconscious and seldom visited recesses, while the ones that remain closer 'to the surface' have been ranked as most 'helpful' to the psyche during its earliest and/or most trialing experiences. By organizing and ranking information this way, this is what makes recall easier and what affords the psyche enough brain power to conscious interact with its environment without getting bogged down by the specifics of sorting information. Those first barriers that sort through stimuli are what shape the basis of our identity.
Given what we know about savants--true savants-- and their remarkable no-holds access to their minds, it makes sense. Savants typically do not demonstrate the same building blocks of personality ( pattern filters) that people with regular recall do. The key here, then, does some to indicate that we're indebted to the organizational parameters of our own minds.
That pretty much the round-about summary of Jungian psychology.