I really do like the concept of getting wet wired. I might not mind opting for a new set of eyes that give me perfect vision with enhanced night vision and thermographic settings. Bone reinforcement and wired reflexes would be nice too, I think synthetic muscle replacement would be the last thing I'd worry about...maybe if I saw the need to pick up a car or rip a tree out of the ground it'd go well with the bone reinforcement.
Little more paranoid when it comes to fiddling with the gray matter though. I can imagine things going horribly wrong with any sort of cybernetic modifications and I don't need some little computer chip turning me into a homicidal maniac.
Yeah, I used to GM many Shadowrun games in my youth.