Yep. In my game, I'm using a new mythology, history, world map, and cosmology.
I've limited the races you can PC, unless you can come up with a VIABLE and acceptable reason why they exist, where, and how they interact with the societies, empires and cultures I've created. However, I allow people to substitute a 4 D6 roll for Stats (take highest three D6), for this array: 18, 16, 16, 15, 12, 10, if they want to.